ACSS1

Across TCGA patient cohorts, ACSS1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACSS1-associated genes across cancer lineages are A-Raf_pS299, STAT5a, and ATM. Each is linked with ACSS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACSS1-to-partner and partner-to-ACSS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ACSS1-low versus ACSS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSS1→partner) and Y-score (partner→ACSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.141	-3.321	.004	.010	3	2
UCEC	STAT5a →	+0.569	+3.459	<.001	.005	3	2
UCEC	ATM →	-0.539	-3.000	.003	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.671	+2.321	.006	.006	3	2
UCEC	4E-BP1 →	+0.239	+3.199	.033	.009	3	2
UCEC	Di-Ras3 →	-0.127	-3.156	.037	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

A-Raf_pS299 by ACSS1 expression — UCEC

Explore this box plot interactively →