ACSS1

Across TCGA pan-cancer cohorts, ACSS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ACSS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ACSS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ACSS1 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and KIRP are the cancer types where ACSS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACSS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.808	<.001	11	view →
LUAD	Male	III,IV	−1.745	<.001	9	view →
KIRP	Male	III,IV	−1.359	<.001	8	view →
KIRC	Male	II,III,IV	−1.058	<.001	8	view →
HNSC	Male	III,IV	+1.164	<.001	6	view →
CHOL	Female	All	+3.506	<.001	5	view →
COAD	All	All	+0.711	<.001	5	view →
LIHC	All	All	+0.619	<.001	4	view →
READ	Female	All	+0.799	.016	2	view →
PRAD	All	All	+0.761	<.001	2	view →
UCEC	All	All	−0.748	.014	2	view →
BRCA	All	III,IV	+0.620	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ACSS1–THCA

Open the THCA breakdown →