ACSS1

Across TCGA cell cohorts, ACSS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,757 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACSS1-associated GO terms across cancer lineages are Short-chain fatty acid biosynthetic process, Short-chain fatty acid metabolic process, and Cellular respiration. Each is linked with ACSS1 in more than 11 cancer types. Because this analysis shows association rather than direction, both ACSS1-to-partner and partner-to-ACSS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Short-chain fatty acid biosynthetic process grouped by ACSS1-low versus ACSS1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSS1→partner) and Y-score (partner→ACSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Short-chain fatty acid biosynthetic process →	+0.710	+1.695	<.001	<.001	3	12
STOMACH	Short-chain fatty acid metabolic process →	+0.129	+2.025	<.001	.002	3	10
UPPER_AERODIGESTIVE_TRACT	Cellular respiration →	+0.089	+1.698	<.001	.001	3	9
BONE	2-oxoglutarate decarboxylation to succinyl-CoA →	+0.084	+1.963	.006	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Aerobic respiration →	+0.103	+1.860	<.001	<.001	3	8
KIDNEY	Regulation of protein localization to endoplasmic reticulum →	+0.118	+1.269	.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,757 associations by consensus.

Short-chain fatty acid biosynthetic process by ACSS1 expression — LUNG_SCLC

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