ACSS1

Across TCGA cell cohorts, ACSS1 mutation is significantly associated with the drug of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACSS1-associated genes across cancer lineages are Niraparib, Luminespib, and ETP-45835. Each is linked with ACSS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACSS1-to-partner and partner-to-ACSS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by ACSS1-low versus ACSS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSS1→partner) and Y-score (partner→ACSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.389	+2.868	.020	.022	3	1
LARGE_INTESTINE	Luminespib →	+0.623	+2.868	.030	.022	3	1
LARGE_INTESTINE	ETP-45835 →	+0.235	+2.874	.040	.021	3	1
LARGE_INTESTINE	Cytarabine →	+0.767	+2.655	.049	.044	2	1
LARGE_INTESTINE	Dinaciclib →	+0.537	+2.868	.027	.022	2	1
LARGE_INTESTINE	SB505124 →	-0.444	-2.807	.045	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Niraparib by ACSS1 expression — LARGE_INTESTINE

Explore this box plot interactively →