Across TCGA cell cohorts, ACSM4 mutation is significantly associated with the RNA expression of many other genes, with 134 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACSM4-associated genes across cancer lineages are MFRP, PPIAL4E, and SLC39A7. Each is linked with ACSM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACSM4-to-partner and partner-to-ACSM4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSM4→partner) and Y-score (partner→ACSM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MFRP →	+0.019	+4.099	<.001	<.001	3	1
SKIN	PPIAL4E →	+0.045	+3.347	<.001	.005	3	1
LARGE_INTESTINE	SLC39A7 →	+0.641	+3.212	.003	.006	3	1
LARGE_INTESTINE	NPY →	+0.054	+2.552	<.001	.005	3	1
LARGE_INTESTINE	TRPM4 →	+1.009	+3.212	.003	.006	3	1
LARGE_INTESTINE	MCHR2 →	+0.014	+3.099	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 134 associations by consensus.

Exploration

ACSM4 survival (RNA) · tumor vs normal (RNA) · all ACSM4 data types