ACSF2

Across TCGA patient cohorts, ACSF2 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACSF2-associated genes across cancer lineages are eIF4E, INPP4B, and Notch1. Each is linked with ACSF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACSF2-to-partner and partner-to-ACSF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ACSF2-low versus ACSF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSF2→partner) and Y-score (partner→ACSF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.217	+2.584	.027	.011	3	1
UCEC	INPP4B →	-0.331	-3.169	.028	.018	3	1
UCEC	Notch1 →	+0.226	+2.820	<.001	.035	3	1
UCEC	p62 Lck ligand →	+0.412	+3.169	.006	.018	3	1
UCEC	Paxillin →	+0.239	+2.584	.047	.011	3	1
UCEC	Src_pY416 →	-0.260	-2.973	.020	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

eIF4E by ACSF2 expression — UCEC

Explore this box plot interactively →