ACSF2

Across TCGA pan-cancer cohorts, ACSF2 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated ACSF2 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ACSF2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ACSF2 expression acts as an unfavorable survival marker, although some lineages such as UVM and BRCA show a favorable association.

UVM, KICH, and BRCA are the cancer types where ACSF2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.859	0.389	<.001	122	view →
KICH	OS	Tertile	All	0.397	1.000	<.001	99	view →
BRCA	OS	Tertile	All	0.974	0.938	<.001	83	view →
MESO	OS	Tertile	II,III,IV	0.568	0.254	<.001	63	view →
ACC	OS	Tertile	II,III,IV	0.822	0.442	.001	46	view →
LUAD	OS	Median	II,III,IV	0.769	0.647	.008	45	view →
LGG	OS	Median	All	0.363	0.514	<.001	42	view →
LAML	DFS	Quartile	All	0.348	0.684	<.001	42	view →
LUSC	OS	Median	II,III,IV	0.534	0.718	<.001	33	view →
STAD	DFS	Median	All	0.308	0.471	.006	26	view →
DLBC	DFS	Median	III,IV	0.873	0.180	.007	23	view →
THCA	DFS	Median	IV	0.475	0.787	.013	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

ACSF2–UVM (OS)

Open the UVM breakdown →