ACSF2

Across TCGA cell cohorts, ACSF2 mutation is significantly associated with the mutation status of many other genes, with 3,007 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACSF2-associated genes across cancer lineages are ZNF391, LARGE1, and DCX. Each is linked with ACSF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACSF2-to-partner and partner-to-ACSF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF391 grouped by ACSF2-low versus ACSF2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSF2→partner) and Y-score (partner→ACSF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZNF391 →	+4.239	+5.053	.007	.007	1	3
SKIN	LARGE1 →	+4.239	+5.053	.007	.007	1	3
SKIN	DCX →	+4.824	+5.392	.004	.004	1	3
BLOOD_Leukemia	UBR1 →	+3.662	+3.523	<.001	<.001	1	3
BLOOD_Leukemia	ARHGAP29 →	+2.855	+3.025	.003	.003	1	3
BLOOD_Leukemia	MMRN1 →	+2.855	+3.025	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,007 associations by consensus.

ZNF391 by ACSF2 expression — SKIN

Explore this box plot interactively →