ACSBG2

Across TCGA patient cohorts, ACSBG2 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACSBG2-associated genes across cancer lineages are HER3_pY1289, JNK2, and p62 Lck ligand. Each is linked with ACSBG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACSBG2-to-partner and partner-to-ACSBG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by ACSBG2-low versus ACSBG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSBG2→partner) and Y-score (partner→ACSBG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.058	+1.316	.034	.015	3	2
UCEC	JNK2 →	+0.214	+1.777	<.001	.002	3	2
UCEC	p62 Lck ligand →	+0.283	+2.584	.006	.010	3	2
UCEC	ASNS →	+0.341	+1.523	.003	.008	3	2
UCEC	ATM →	-0.507	-2.893	<.001	.001	3	2
UCEC	beta-Catenin →	+0.396	+1.765	.014	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

HER3_pY1289 by ACSBG2 expression — UCEC

Explore this box plot interactively →