ACSBG2

Across TCGA pan-cancer cohorts, ACSBG2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ACSBG2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ACSBG2 RNA is repressed in tumor relative to normal tissue. In most cancer types ACSBG2 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and HNSC are the cancer types where ACSBG2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACSBG2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	−0.987	<.001	11	view →
KIRC	Male	All	−0.490	<.001	9	view →
HNSC	All	All	+0.075	<.001	8	view →
LIHC	All	All	+0.080	<.001	7	view →
BRCA	Female	All	−0.190	<.001	6	view →
KICH	All	II,III,IV	−0.618	<.001	5	view →
BLCA	All	All	+0.130	.016	5	view →
COAD	All	All	+0.082	.001	4	view →
CHOL	All	All	+0.322	<.001	2	view →
LUAD	Male	All	−0.108	.018	2	view →
THCA	All	All	−0.041	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ACSBG2–KIRP

Open the KIRP breakdown →