ACRBP

Across TCGA patient cohorts, ACRBP mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ACRBP-associated genes across cancer lineages are Fibronectin, MSH6, and PRAS40_pT246. Each is linked with ACRBP in more than 1 cancer types. Because this analysis shows association rather than direction, both ACRBP-to-partner and partner-to-ACRBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by ACRBP-low versus ACRBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACRBP→partner) and Y-score (partner→ACRBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.380	-3.308	.008	.009	3	1
UCEC	MSH6 →	-0.376	-3.169	.009	.018	3	1
UCEC	PRAS40_pT246 →	+0.182	+1.598	.015	.044	3	1
UCEC	Annexin-1 →	+0.603	+3.341	.008	.005	3	1
COAD	FASN →	+0.610	+2.815	.004	.036	3	1
SKCM	Caspase-7-cleavedD198 →	+0.647	+2.832	.040	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Fibronectin by ACRBP expression — UCEC

Explore this box plot interactively →