ACRBP

Across TCGA cell cohorts, ACRBP mutation is significantly associated with the drug of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACRBP-associated genes across cancer lineages are SB590885, Zoledronate, and LIMK1 inhibitor BMS4. Each is linked with ACRBP in more than 1 cancer types. Because this analysis shows association rather than direction, both ACRBP-to-partner and partner-to-ACRBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SB590885 grouped by ACRBP-low versus ACRBP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACRBP→partner) and Y-score (partner→ACRBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SB590885 →	+0.650	+2.807	.007	.046	3	1
LARGE_INTESTINE	Zoledronate →	+0.270	+2.847	.034	.020	3	1
LARGE_INTESTINE	LIMK1 inhibitor BMS4 →	+0.400	+3.201	.013	.006	3	1
LARGE_INTESTINE	ETP-45835 →	+0.279	+3.067	.009	.009	3	1
LARGE_INTESTINE	CD532 →	+0.401	+3.067	.028	.009	3	1
LARGE_INTESTINE	Tanespimycin →	+0.631	+2.807	.009	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

SB590885 by ACRBP expression — LARGE_INTESTINE

Explore this box plot interactively →