ACP4

Across TCGA patient cohorts, ACP4 mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. CESC shows the largest number of these associations.

The most reproducible ACP4-associated genes across cancer lineages are CD8+ Tcm, Skeletal muscle, and CD8+ T-cells. Each is linked with ACP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACP4-to-partner and partner-to-ACP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ Tcm grouped by ACP4-low versus ACP4-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACP4→partner) and Y-score (partner→ACP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	CD8+ Tcm →	+0.069	+3.503	.007	.012	3	2
SKCM	Skeletal muscle →	+0.057	+2.813	.012	.037	2	2
CESC	CD8+ T-cells →	+0.034	+4.345	.025	.002	3	1
CESC	DC →	+0.035	+2.937	.011	.048	3	1
CESC	CD4+ memory T-cells →	+0.038	+3.605	.001	.014	3	1
UCEC	CMP →	+0.042	+3.332	.007	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CD8+ Tcm by ACP4 expression — CESC

Explore this box plot interactively →