ACP4

Across TCGA pan-cancer cohorts, ACP4 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ACP4 data layer compared with 4 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher ACP4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ACP4 expression acts as an unfavorable survival marker, although some lineages such as THYM and BRCA show a favorable association.

MESO, KIRC, and KICH are the cancer types where ACP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.415	0.681	<.001	115	view →
KIRC	DFS	Tertile	III,IV	0.497	0.754	.001	112	view →
KICH	DFS	Quartile	All	0.691	1.000	.011	41	view →
READ	DFS	Tertile	II,III,IV	0.330	0.698	.006	37	view →
LIHC	OS	Tertile	All	0.598	0.795	<.001	34	view →
SCLC	DFS	Median	III,IV	0.338	0.968	.024	24	view →
PRAD	DFS	Median	All	0.708	0.871	.001	18	view →
THYM	DFS	Median	All	0.956	0.779	.003	15	view →
THCA	OS	Median	II,III,IV	0.932	1.000	.016	14	view →
ACC	DFS	Median	All	0.446	0.779	.002	14	view →
LUAD	OS	Quartile	All	0.246	0.459	.015	11	view →
BRCA	OS	Median	IV	0.800	0.341	.003	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ACP4–MESO (OS)

Open the MESO breakdown →