ACP3

Across TCGA cell cohorts, ACP3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACP3-associated genes across cancer lineages are BPIFB6, VWC2L, and DBX2. Each is linked with ACP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACP3-to-partner and partner-to-ACP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFB6 grouped by ACP3-low versus ACP3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACP3→partner) and Y-score (partner→ACP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BPIFB6 →	+0.020	+4.437	<.001	.004	3	1
LARGE_INTESTINE	VWC2L →	+0.011	+3.930	<.001	.003	3	1
LARGE_INTESTINE	DBX2 →	+0.015	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	ADH1A →	+0.130	+3.920	.001	.005	3	1
LARGE_INTESTINE	OR2J1 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	MYOCOS →	+0.073	+4.444	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

BPIFB6 by ACP3 expression — LARGE_INTESTINE

Explore this box plot interactively →