ACP3

Across TCGA pan-cancer cohorts, ACP3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ACP3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ACP3 RNA is repressed in tumor relative to normal tissue. In most cancer types ACP3 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where ACP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−4.151	<.001	12	view →
KIRP	Male	II,III,IV	−4.622	<.001	11	view →
KICH	Male	IV	−4.176	<.001	10	view →
HNSC	All	III,IV	−1.480	<.001	10	view →
THCA	All	II,III,IV	+0.414	.001	8	view →
BLCA	Male	All	+1.081	.005	4	view →
COAD	All	II,III,IV	+0.616	.008	3	view →
CHOL	All	All	+0.865	<.001	2	view →
LUAD	Male	II,III,IV	−0.649	.037	2	view →
UCEC	All	All	+0.615	.027	2	view →
LUSC	All	All	+0.416	.019	2	view →
BRCA	All	II,III,IV	+0.214	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ACP3–KIRC

Open the KIRC breakdown →