ACOXL

Across TCGA patient cohorts, ACOXL mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACOXL-associated genes across cancer lineages are EGFR_pY1068, mTOR_pS2448, and Myosin-IIa_pS1943. Each is linked with ACOXL in more than 1 cancer types. Because this analysis shows association rather than direction, both ACOXL-to-partner and partner-to-ACOXL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ACOXL-low versus ACOXL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOXL→partner) and Y-score (partner→ACOXL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.313	-2.415	.001	.003	3	2
UCEC	mTOR_pS2448 →	-0.146	-2.302	.015	.034	3	2
UCEC	Myosin-IIa_pS1943 →	+0.199	+1.920	.016	.009	3	2
UCEC	Beclin →	-0.087	-3.169	.021	.018	3	2
UCEC	14-3-3_beta →	-0.131	-3.558	.001	.002	3	1
UCEC	eEF2 →	+0.380	+3.169	.008	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

EGFR_pY1068 by ACOXL expression — UCEC

Explore this box plot interactively →