ACOXL

Across TCGA pan-cancer cohorts, ACOXL RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ACOXL’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ACOXL RNA is repressed in tumor relative to normal tissue. In most cancer types ACOXL is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and BRCA are the cancer types where ACOXL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACOXL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−2.852	<.001	9	view →
LUAD	Male	II,III,IV	−2.363	<.001	9	view →
BRCA	Female	II,III,IV	+0.197	<.001	6	view →
HNSC	All	All	+0.075	.005	5	view →
LIHC	All	All	+0.039	<.001	4	view →
CHOL	All	All	+0.326	.002	3	view →
READ	All	All	−0.217	<.001	3	view →
KICH	Male	IV	−0.153	.015	3	view →
UCEC	All	All	+0.301	.033	2	view →
KIRC	All	All	−0.068	.045	2	view →
STAD	All	All	+0.126	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ACOXL–LUSC

Open the LUSC breakdown →