ACOXL

Across TCGA cell cohorts, ACOXL mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible ACOXL-associated genes across cancer lineages are C1QC, MAGEB5, and SPRR2F. Each is linked with ACOXL in more than 1 cancer types. Because this analysis shows association rather than direction, both ACOXL-to-partner and partner-to-ACOXL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QC grouped by ACOXL-low versus ACOXL-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOXL→partner) and Y-score (partner→ACOXL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	C1QC →	+0.013	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
CNS	SPRR2F →	+0.139	+4.169	<.001	.008	3	1
BLOOD_Leukemia	DRD3 →	+0.012	+5.201	<.001	.006	3	1
LUNG_NSCLC_LUAD	OCM2 →	+0.045	+5.662	<.001	.002	3	1
SKIN	C2CD4B →	+0.041	+4.684	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

C1QC by ACOXL expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →