ACOX3

Across TCGA cell cohorts, ACOX3 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACOX3-associated genes across cancer lineages are SNPH, C6orf118, and PLVAP. Each is linked with ACOX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACOX3-to-partner and partner-to-ACOX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNPH grouped by ACOX3-low versus ACOX3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOX3→partner) and Y-score (partner→ACOX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SNPH →	+0.941	+3.215	.001	.009	3	1
LARGE_INTESTINE	C6orf118 →	+0.118	+2.793	<.001	.002	3	1
LARGE_INTESTINE	PLVAP →	+0.181	+3.761	.003	.001	3	1
LARGE_INTESTINE	TBR1 →	+0.039	+3.748	<.001	.001	3	1
LARGE_INTESTINE	ACER1 →	+0.064	+2.823	.007	.002	3	1
LARGE_INTESTINE	OR2C1 →	+0.108	+3.047	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

SNPH by ACOX3 expression — LARGE_INTESTINE

Explore this box plot interactively →