ACOT8

Across TCGA patient cohorts, ACOT8 protein abundance is significantly associated with the RNA expression of many other genes, with 11,554 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ACOT8-associated genes across cancer lineages are CTSA, TMEM220, and FHL5. Each is linked with ACOT8 in more than 6 cancer types. Because this analysis shows association rather than direction, both ACOT8-to-partner and partner-to-ACOT8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACOT8 versus CTSA in COAD, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOT8→partner) and Y-score (partner→ACOT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CTSA →	+0.843	+0.388	<.001	<.001	3	7
UCEC	TMEM220 →	-0.859	-0.296	<.001	.001	3	6
UCEC	FHL5 →	-0.808	-0.286	<.001	<.001	3	5
CCRCC	DNTTIP1 →	+0.659	+0.329	.001	.001	3	5
GBM	SDC4 →	+1.093	+0.437	<.001	<.001	3	5
COAD	PIGT →	+0.560	+0.396	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,554 associations by consensus.

ACOT8 vs CTSA — COAD

Explore this scatter interactively →