ACOT8

Across TCGA patient cohorts, ACOT8 mutation is significantly associated with the RNA expression of many other genes, with 199 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACOT8-associated genes across cancer lineages are RNU6-741P, LINC00709, and RNU2-44P. Each is linked with ACOT8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACOT8-to-partner and partner-to-ACOT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-741P grouped by ACOT8-low versus ACOT8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOT8→partner) and Y-score (partner→ACOT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-741P →	+0.148	+4.212	<.001	.007	3	2
LUAD	LINC00709 →	+0.049	+7.930	<.001	.008	3	2
LUAD	RNU2-44P →	+0.203	+7.930	<.001	.008	3	2
LUAD	RNU6-165P →	+0.352	+7.930	<.001	.008	3	2
CESC	RNA5SP422 →	+0.413	+7.164	<.001	<.001	3	2
UCEC	SOCAR →	+0.337	+3.499	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 199 associations by consensus.

RNU6-741P by ACOT8 expression — SKCM

Explore this box plot interactively →