ACOT13

Across TCGA patient cohorts, ACOT13 mutation is significantly associated with the RNA expression of many other genes, with 493 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACOT13-associated genes across cancer lineages are RNY4P27, RNU1-44P, and RNA5SP451. Each is linked with ACOT13 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACOT13-to-partner and partner-to-ACOT13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY4P27 grouped by ACOT13-low versus ACOT13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOT13→partner) and Y-score (partner→ACOT13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNY4P27 →	+0.204	+3.579	<.001	.002	3	2
UCEC	RNU1-44P →	+0.310	+2.790	<.001	.002	3	2
UCEC	RNA5SP451 →	+0.323	+2.977	<.001	.009	3	2
UCEC	PCNPP2 →	+0.072	+3.351	<.001	.004	3	2
UCEC	EIF3JP1 →	+0.189	+2.690	<.001	.001	3	2
UCEC	LINC02114 →	+0.109	+2.567	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 493 associations by consensus.

RNY4P27 by ACOT13 expression — UCEC

Explore this box plot interactively →