Across TCGA patient cohorts, ACOT1 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACOT1-associated genes across cancer lineages are CHCHD2P3, LINC01050, and TRAJ60. Each is linked with ACOT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACOT1-to-partner and partner-to-ACOT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOT1→partner) and Y-score (partner→ACOT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHCHD2P3 →	+0.273	+3.603	<.001	.004	3	1
UCEC	LINC01050 →	+0.305	+3.801	.003	.005	3	1
SKCM	TRAJ60 →	+0.772	+5.097	<.001	.008	3	1
UCEC	MIR103A1 →	+0.345	+5.470	<.001	.001	3	1
UCEC	RNU1-24P →	+0.216	+4.722	.006	.004	3	1
UCEC	RNY1P8 →	+0.637	+4.453	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

ACOT1 survival (RNA) · tumor vs normal (RNA) · all ACOT1 data types