ACO2

Across TCGA patient cohorts, ACO2 mutation is significantly associated with the RNA expression of many other genes, with 3,134 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACO2-associated genes across cancer lineages are H2BC2P, RN7SL496P, and FAM223B. Each is linked with ACO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACO2-to-partner and partner-to-ACO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC2P grouped by ACO2-low versus ACO2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACO2→partner) and Y-score (partner→ACO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	H2BC2P →	+0.071	+4.246	<.001	<.001	3	2
LUSC	RN7SL496P →	+0.144	+5.273	.003	.006	3	2
LUSC	FAM223B →	+0.062	+5.882	<.001	.002	3	2
SKCM	MIR5689 →	+0.208	+3.645	<.001	.003	3	2
SKCM	MIR4510 →	+0.138	+4.485	<.001	.004	3	2
UCEC	ALDOA →	+0.388	+1.874	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,134 associations by consensus.

H2BC2P by ACO2 expression — SKCM

Explore this box plot interactively →