ACO1

Across TCGA patient cohorts, ACO1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,825 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ACO1-associated genes across cancer lineages are PDE1A, MAN1C1, and ADH1B. Each is linked with ACO1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ACO1-to-partner and partner-to-ACO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACO1 versus PDE1A in OV, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACO1→partner) and Y-score (partner→ACO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PDE1A →	+1.569	+0.425	<.001	<.001	3	6
BRCA	MAN1C1 →	+0.670	+0.343	<.001	.002	3	6
BRCA	ADH1B →	+2.380	+0.459	<.001	<.001	3	6
UCEC	ARHGAP20 →	+0.682	+0.276	.005	.001	3	5
BRCA	HNMT →	+0.806	+0.492	<.001	<.001	3	5
LSCC	NR3C2 →	+0.798	+0.271	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,825 associations by consensus.

ACO1 vs PDE1A — OV

Explore this scatter interactively →