ACO1

Across TCGA patient cohorts, ACO1 mutation is significantly associated with the RNA expression of many other genes, with 1,350 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACO1-associated genes across cancer lineages are RHBDD3, PSMC3IP, and MIR6070. Each is linked with ACO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACO1-to-partner and partner-to-ACO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RHBDD3 grouped by ACO1-low versus ACO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACO1→partner) and Y-score (partner→ACO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RHBDD3 →	+0.387	+2.736	<.001	<.001	3	3
UCEC	PSMC3IP →	+0.505	+2.161	<.001	<.001	3	3
LIHC	MIR6070 →	+0.464	+5.878	<.001	.002	3	2
CESC	IGHD5-24 →	+1.758	+5.669	<.001	.003	3	2
LIHC	NDUFB4P4 →	+0.226	+6.008	<.001	.002	3	2
BRCA	MIR517C →	+0.163	+7.471	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,350 associations by consensus.

RHBDD3 by ACO1 expression — UCEC

Explore this box plot interactively →