ACMSD

Across TCGA patient cohorts, ACMSD protein abundance is significantly associated with the RNA expression of many other genes, with 870 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible ACMSD-associated genes across cancer lineages are DMC1, PNPLA3, and NDFIP2. Each is linked with ACMSD in more than 1 cancer types. Because this analysis shows association rather than direction, both ACMSD-to-partner and partner-to-ACMSD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACMSD versus DMC1 in CCRCC, with a Pearson correlation of -0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACMSD→partner) and Y-score (partner→ACMSD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DMC1 →	-0.406	-0.427	.009	.008	3	1
CCRCC	PNPLA3 →	+0.729	+0.477	<.001	<.001	3	1
CCRCC	NDFIP2 →	+0.544	+0.495	.002	.003	3	1
CCRCC	DNAJC3 →	+0.299	+0.420	.001	.003	3	1
CCRCC	PLA2G15 →	+0.399	+0.445	<.001	<.001	3	1
CCRCC	SGK3 →	+0.254	+0.409	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 870 associations by consensus.

ACMSD vs DMC1 — CCRCC

Explore this scatter interactively →