ACMSD

Across TCGA pan-cancer cohorts, ACMSD RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ACMSD data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ACMSD RNA is associated with better overall survival. In most high-consensus cancer types, elevated ACMSD expression acts as an unfavorable survival marker, although some lineages such as KIRC and BLCA show a favorable association.

KIRC, BLCA, and SCLC are the cancer types where ACMSD RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.727	0.525	<.001	151	view →
BLCA	OS	Median	All	0.536	0.338	<.001	62	view →
SCLC	OS	Median	II,III,IV	0.870	0.563	.001	57	view →
HNSC	DFS	Tertile	IV	0.727	0.541	.003	55	view →
LGG	OS	Median	All	0.320	0.528	<.001	54	view →
KIRP	OS	Median	All	0.933	0.832	.008	46	view →
CHOL	DFS	Quartile	All	0.162	0.671	.008	17	view →
UCEC	OS	Median	II,III,IV	0.814	0.889	.012	16	view →
MESO	OS	Median	III,IV	0.178	0.676	.001	15	view →
CESC	DFS	Median	All	0.786	0.852	.024	12	view →
SKCM	DFS	Tertile	All	0.641	0.523	.015	12	view →
ESCA	DFS	Tertile	III,IV	0.482	0.236	.035	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ACMSD–KIRC (OS)

Open the KIRC breakdown →