ACMSD

Across TCGA patient cohorts, ACMSD mutation is significantly associated with the RNA expression of many other genes, with 1,070 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACMSD-associated genes across cancer lineages are ADAM33, PTH1R, and STOML2. Each is linked with ACMSD in more than 1 cancer types. Because this analysis shows association rather than direction, both ACMSD-to-partner and partner-to-ACMSD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM33 grouped by ACMSD-low versus ACMSD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACMSD→partner) and Y-score (partner→ACMSD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ADAM33 →	-0.811	-3.576	.008	.002	3	2
UCEC	PTH1R →	-0.711	-3.679	.009	.001	3	2
UCEC	STOML2 →	+0.447	+2.087	.004	.006	3	2
UCEC	ZMYND19 →	+0.585	+3.280	<.001	<.001	3	2
UCEC	SAAL1 →	+0.439	+3.595	.007	.001	3	2
UCEC	CHAF1A →	+0.541	+2.108	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,070 associations by consensus.

ADAM33 by ACMSD expression — UCEC

Explore this box plot interactively →