ACMSD

Across TCGA patient cohorts, ACMSD mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACMSD-associated genes across cancer lineages are Notch1, Ku80, and STAT3_pY705. Each is linked with ACMSD in more than 3 cancer types. Because this analysis shows association rather than direction, both ACMSD-to-partner and partner-to-ACMSD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ACMSD-low versus ACMSD-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACMSD→partner) and Y-score (partner→ACMSD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Notch1 →	+0.246	+3.182	.001	.009	3	4
UCEC	Ku80 →	+0.200	+2.009	.027	.017	3	2
UCEC	STAT3_pY705 →	-0.405	-1.807	<.001	.024	3	2
UCEC	eEF2 →	+0.388	+2.000	.004	.030	3	1
UCEC	EGFR_pY1068 →	-0.263	-2.087	.006	.005	3	1
UCEC	A-Raf_pS299 →	-0.121	-2.115	.008	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Notch1 by ACMSD expression — SKCM

Explore this box plot interactively →