ACMSD

Across TCGA cell cohorts, ACMSD mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACMSD-associated genes across cancer lineages are OR2M5, TBC1D21, and OR52H1. Each is linked with ACMSD in more than 1 cancer types. Because this analysis shows association rather than direction, both ACMSD-to-partner and partner-to-ACMSD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M5 grouped by ACMSD-low versus ACMSD-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACMSD→partner) and Y-score (partner→ACMSD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2M5 →	+0.018	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR52H1 →	+0.027	+3.669	<.001	<.001	3	1
LARGE_INTESTINE	CCDC195 →	+0.037	+3.297	.001	.002	3	1
LARGE_INTESTINE	C10orf90 →	+0.120	+3.333	.002	.009	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR2M5 by ACMSD expression — LARGE_INTESTINE

Explore this box plot interactively →