ACIN1

Across TCGA pan-cancer cohorts, ACIN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ACIN1 data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ACIN1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ACIN1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where ACIN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	IV	0.636	0.990	.001	88	view →
PDAC	OS	Quartile	All	0.663	0.413	.008	29	view →
LUAD	OS	Tertile	III,IV	1.000	0.643	.006	16	view →
COAD	DFS	Median	All	1.000	0.886	.020	12	view →
CCRCC	OS	Median	IV	1.000	0.202	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ACIN1–HNSC (OS)

Open the HNSC breakdown →