ACIN1

Across TCGA pan-cancer cohorts, ACIN1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ACIN1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ACIN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ACIN1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, LIHC, and BLCA are the cancer types where ACIN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACIN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.663	<.001	11	view →
LIHC	Female	II,III,IV	+1.165	<.001	8	view →
BLCA	All	All	+0.456	.001	8	view →
STAD	All	II,III,IV	+0.708	<.001	6	view →
CHOL	Male	All	+2.306	<.001	5	view →
KIRP	All	IV	+0.867	.006	5	view →
LUSC	Male	II,III,IV	+0.483	<.001	5	view →
COAD	All	All	+0.219	.008	4	view →
ESCA	All	All	+0.588	.005	2	view →
KICH	All	All	−0.438	.006	2	view →
LUAD	All	All	+0.227	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ACIN1–HNSC

Open the HNSC breakdown →