ACIN1

Across TCGA cell cohorts, ACIN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,696 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACIN1-associated GO terms across cancer lineages are Regulation of mRNA splicing, via spliceosome, Regulation of double-strand break repair via homologous recombination, and Nuclear export. Each is linked with ACIN1 in more than 19 cancer types. Because this analysis shows association rather than direction, both ACIN1-to-partner and partner-to-ACIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA splicing, via spliceosome grouped by ACIN1-low versus ACIN1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACIN1→partner) and Y-score (partner→ACIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA splicing, via spliceosome →	+0.112	+1.016	<.001	<.001	3	20
SOFT_TISSUE	Regulation of double-strand break repair via homologous recombination →	+0.105	+1.184	<.001	<.001	3	19
OESOPHAGUS	Nuclear export →	+0.102	+0.739	.001	<.001	3	18
STOMACH	Heterochromatin formation →	+0.076	+0.918	.001	<.001	3	18
OVARY	Negative regulation of RNA splicing →	+0.096	+0.895	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Regulation of alternative mRNA splicing, via spliceosome →	+0.126	+0.959	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,696 associations by consensus.

Regulation of mRNA splicing, via spliceosome by ACIN1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →