ACHE

Across TCGA patient cohorts, ACHE protein abundance is significantly associated with the RNA expression of many other genes, with 5,261 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ACHE-associated genes across cancer lineages are AOC3, FBN2, and PDLIM3. Each is linked with ACHE in more than 1 cancer types. Because this analysis shows association rather than direction, both ACHE-to-partner and partner-to-ACHE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACHE versus AOC3 in HNSC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACHE→partner) and Y-score (partner→ACHE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AOC3 →	+0.658	+0.416	.002	.002	3	2
GBM	FBN2 →	-1.398	-0.427	.003	.001	3	2
HNSC	PDLIM3 →	+1.733	+0.378	<.001	.003	3	2
GBM	TREML4 →	+0.603	+0.420	.001	.001	3	2
HNSC	TMEM233 →	+0.698	+0.438	.001	<.001	3	2
HNSC	LINC00702 →	+0.967	+0.419	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,261 associations by consensus.

ACHE vs AOC3 — HNSC

Explore this scatter interactively →