ACER3

Across TCGA patient cohorts, ACER3 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACER3-associated genes across cancer lineages are JNK2, MEK1, and PDK1_pS241. Each is linked with ACER3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACER3-to-partner and partner-to-ACER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by ACER3-low versus ACER3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACER3→partner) and Y-score (partner→ACER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.234	+2.817	.015	.036	3	1
UCEC	MEK1 →	+0.384	+3.584	.029	.002	3	1
UCEC	PDK1_pS241 →	+0.195	+2.196	.018	.032	3	1
UCEC	Rictor_pT1135 →	-0.117	-2.459	.018	.020	3	1
UCEC	VHL →	-0.827	-3.321	.011	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.886	+2.459	.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

JNK2 by ACER3 expression — UCEC

Explore this box plot interactively →