ACER3

Across TCGA pan-cancer cohorts, ACER3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ACER3’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where ACER3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ACER3 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

STAD, LIHC, and KICH are the cancer types where ACER3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACER3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	II,III,IV	+0.919	<.001	10	view →
LIHC	All	II,III,IV	+0.880	<.001	9	view →
KICH	All	II,III,IV	−0.682	<.001	9	view →
KIRC	Male	All	+0.366	<.001	9	view →
HNSC	Male	All	+0.702	<.001	8	view →
LUAD	Female	III,IV	−0.835	<.001	6	view →
UCEC	All	II,III,IV	+0.831	.001	6	view →
COAD	Female	All	−0.685	<.001	6	view →
THCA	All	All	−0.253	.002	5	view →
CHOL	Female	All	+1.996	<.001	3	view →
ESCA	All	All	+1.000	.001	3	view →
PRAD	All	All	+0.516	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ACER3–STAD

Open the STAD breakdown →