ACER3

Across TCGA cell cohorts, ACER3 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACER3-associated genes across cancer lineages are PRSS54, OR2T8, and PTH2R. Each is linked with ACER3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACER3-to-partner and partner-to-ACER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS54 grouped by ACER3-low versus ACER3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACER3→partner) and Y-score (partner→ACER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRSS54 →	+0.038	+3.345	<.001	.007	3	1
LARGE_INTESTINE	OR2T8 →	+0.162	+3.693	.002	.005	3	1
LARGE_INTESTINE	PTH2R →	+1.076	+3.453	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PRSS54 by ACER3 expression — LARGE_INTESTINE

Explore this box plot interactively →