ACER1

Across TCGA cell cohorts, ACER1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ACER1-associated genes across cancer lineages are OXT, OR1E1, and AVPR1B. Each is linked with ACER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACER1-to-partner and partner-to-ACER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXT grouped by ACER1-low versus ACER1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACER1→partner) and Y-score (partner→ACER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OXT →	+0.063	+4.977	<.001	.007	3	1
SKIN	OR1E1 →	+0.647	+4.977	<.001	.007	3	1
SKIN	AVPR1B →	+0.006	+5.415	.007	.004	3	1
SKIN	TMEM114 →	+0.051	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OXT by ACER1 expression — SKIN

Explore this box plot interactively →