Across TCGA patient cohorts, ACCSL mutation is significantly associated with the RNA expression of many other genes, with 3,807 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACCSL-associated genes across cancer lineages are PKN3, RECQL4, and CHAF1A. Each is linked with ACCSL in more than 2 cancer types. Because this analysis shows association rather than direction, both ACCSL-to-partner and partner-to-ACCSL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACCSL→partner) and Y-score (partner→ACCSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKN3 →	+0.976	+3.403	<.001	<.001	3	3
UCEC	RECQL4 →	+0.754	+3.459	<.001	.005	3	3
UCEC	CHAF1A →	+0.882	+2.758	<.001	<.001	3	3
UCEC	MTHFD2 →	+0.674	+2.238	.001	.006	3	3
UCEC	PPP2R5C →	+0.469	+2.959	<.001	<.001	3	3
UCEC	PALB2 →	+0.424	+1.869	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,807 associations by consensus.

Exploration

ACCSL survival (RNA) · tumor vs normal (RNA) · all ACCSL data types