Across TCGA pan-cancer cohorts, ACCSL RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ACCSL’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where ACCSL RNA is repressed in tumor relative to normal tissue. In most cancer types ACCSL is over-expressed in tumor, although a few such as UCEC and LUAD show the opposite, repressed pattern.

UCEC, KIRC, and LUAD are the cancer types where ACCSL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACCSL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	II,III,IV	−0.156	.001	8	view →
KIRC	All	All	+0.028	<.001	8	view →
LUAD	All	III,IV	−0.035	.003	3	view →
COAD	Male	All	−0.019	.024	2	view →
THCA	Male	III,IV	−0.025	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ACCSL RNA expression & survival · all ACCSL data types