Across TCGA cell cohorts, ACCSL mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACCSL-associated genes across cancer lineages are MARCHF11, MT1H, and GCG. Each is linked with ACCSL in more than 1 cancer types. Because this analysis shows association rather than direction, both ACCSL-to-partner and partner-to-ACCSL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACCSL→partner) and Y-score (partner→ACCSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MARCHF11 →	+0.193	+3.836	.004	.004	3	1
SKIN	MT1H →	+0.186	+4.467	<.001	.004	3	1
BLOOD_Leukemia	GCG →	+0.224	+3.643	.008	.006	3	1
BLOOD_Leukemia	PCDH8 →	+0.988	+3.769	<.001	.004	3	1
BLOOD_Leukemia	TMEM196 →	+0.029	+3.289	<.001	.009	3	1
BLOOD_Leukemia	GSG1L2 →	+0.028	+3.969	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

ACCSL survival (RNA) · tumor vs normal (RNA) · all ACCSL data types