ACAT1

Across TCGA patient cohorts, ACAT1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACAT1-associated genes across cancer lineages are INPP4B, EGFR_pY1068, and ACC_pS79. Each is linked with ACAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACAT1-to-partner and partner-to-ACAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by ACAT1-low versus ACAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAT1→partner) and Y-score (partner→ACAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.325	-2.102	.021	.019	3	2
UCEC	EGFR_pY1068 →	-0.230	-2.115	.036	.019	3	1
UCEC	ACC_pS79 →	+0.328	+2.179	.030	.034	3	1
UCEC	Ku80 →	+0.235	+1.598	.022	.044	3	1
UCEC	MEK1 →	+0.385	+3.459	.016	.005	3	1
UCEC	VHL →	-0.964	-3.459	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

INPP4B by ACAT1 expression — UCEC

Explore this box plot interactively →