ACAT1

Across TCGA pan-cancer cohorts, ACAT1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ACAT1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ACAT1 RNA is repressed in tumor relative to normal tissue. In most cancer types ACAT1 is over-expressed in tumor, although a few such as COAD and KIRP show the opposite, repressed pattern.

COAD, KIRP, and THCA are the cancer types where ACAT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACAT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−1.374	<.001	12	view →
KIRP	Male	III,IV	−1.912	<.001	10	view →
THCA	Male	III,IV	−1.252	<.001	10	view →
BLCA	All	III,IV	−1.152	<.001	10	view →
KIRC	Male	II,III,IV	−1.408	<.001	9	view →
LIHC	All	II,III,IV	−0.970	<.001	9	view →
LUAD	Female	III,IV	−1.195	<.001	8	view →
LUSC	Female	II,III,IV	−1.110	<.001	8	view →
HNSC	Male	All	−0.819	<.001	7	view →
BRCA	All	All	−0.640	<.001	6	view →
READ	All	All	−1.259	<.001	5	view →
UCEC	All	All	−1.193	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ACAT1–COAD

Open the COAD breakdown →