ACAP3

Across TCGA pan-cancer cohorts, ACAP3 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ACAP3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ACAP3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ACAP3 is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

HNSC, PDAC, and CCRCC are the cancer types where ACAP3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACAP3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	−0.273	.003	10	view →
PDAC	Female	All	+0.535	.006	4	view →
CCRCC	Female	IV	−0.388	.021	3	view →
LUAD	All	All	−0.144	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ACAP3–HNSC

Open the HNSC breakdown →