ACADM

Across TCGA patient cohorts, ACADM mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACADM-associated genes across cancer lineages are ATM, INPP4B, and Notch1. Each is linked with ACADM in more than 3 cancer types. Because this analysis shows association rather than direction, both ACADM-to-partner and partner-to-ACADM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ACADM-low versus ACADM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACADM→partner) and Y-score (partner→ACADM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.590	-1.678	<.001	.023	3	4
UCEC	INPP4B →	-0.286	-2.584	.021	.010	3	2
UCEC	Notch1 →	+0.108	+2.183	.045	.033	3	2
UCEC	4E-BP1 →	+0.246	+2.321	.017	.033	3	2
UCEC	JNK2 →	+0.245	+2.087	.001	.005	3	1
UCEC	Ku80 →	+0.192	+1.335	.034	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ATM by ACADM expression — UCEC

Explore this box plot interactively →