ACADM

Across TCGA pan-cancer cohorts, ACADM RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ACADM data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ACADM RNA is associated with better overall survival. In most high-consensus cancer types, elevated ACADM expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

KIRC, LGG, and READ are the cancer types where ACADM RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.780	0.489	<.001	184	view →
LGG	DFS	Median	All	0.655	0.820	<.001	53	view →
READ	OS	Tertile	II,III,IV	1.000	0.299	<.001	35	view →
BRCA	DFS	Median	All	0.967	0.930	.001	31	view →
CESC	DFS	Quartile	IV	0.148	0.693	.011	24	view →
COAD	OS	Median	All	0.907	0.828	.008	17	view →
BLCA	DFS	Tertile	III,IV	0.644	0.364	.009	16	view →
UCEC	DFS	Tertile	All	0.781	0.883	.003	14	view →
LUAD	DFS	Median	II,III,IV	0.728	0.561	.009	13	view →
ACC	DFS	Median	II,III,IV	0.244	0.576	.007	12	view →
KIRP	OS	Quartile	II,III,IV	1.000	0.365	.022	12	view →
KICH	OS	Median	II,III,IV	0.600	1.000	.027	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ACADM–KIRC (OS)

Open the KIRC breakdown →