ACAD9

Across TCGA patient cohorts, ACAD9 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACAD9-associated genes across cancer lineages are PCNA, GAPDH, and 14-3-3_beta. Each is linked with ACAD9 in more than 3 cancer types. Because this analysis shows association rather than direction, both ACAD9-to-partner and partner-to-ACAD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ACAD9-low versus ACAD9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAD9→partner) and Y-score (partner→ACAD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.187	+2.222	.014	.010	3	4
UCEC	GAPDH →	+0.426	+2.999	.024	.035	3	2
UCEC	14-3-3_beta →	-0.082	-3.432	.020	.005	3	1
UCEC	eEF2 →	+0.326	+2.459	.009	.019	3	1
UCEC	EGFR_pY1068 →	-0.192	-2.000	.030	.003	3	1
UCEC	eIF4E →	+0.165	+2.807	.027	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

PCNA by ACAD9 expression — UCEC

Explore this box plot interactively →