ACAD8

Across TCGA cell cohorts, ACAD8 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACAD8-associated genes across cancer lineages are MSGN1, TAFA1, and C14orf180. Each is linked with ACAD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACAD8-to-partner and partner-to-ACAD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by ACAD8-low versus ACAD8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAD8→partner) and Y-score (partner→ACAD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.276	+5.009	<.001	<.001	3	1
LARGE_INTESTINE	C14orf180 →	+0.176	+3.155	<.001	.008	3	1
LARGE_INTESTINE	TAS2R41 →	+0.040	+3.345	<.001	.007	3	1
BLOOD_Leukemia	HHATL →	+0.056	+3.816	.001	.004	3	1
BLOOD_Leukemia	GSC →	+1.303	+3.948	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MSGN1 by ACAD8 expression — LARGE_INTESTINE

Explore this box plot interactively →